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Bisphosphonates

Bisphosphonates are a class of drug designed to strengthen bones and include brand names Actonel, Aredia, Boniva, Fosamax, Skelid and Zometa.  They are commonly prescribed in cases of osteoporosis, bone cancer and other bone-weakening diseases.  Common side effects include rash, bone pain, and gastrointestinal symptoms; however, bisphosphonates have recently been linked to osteonecrosis of the jaw ("dead jaw syndrome"), a wasting disease in which bone tissue dies.  Experts concede that the drug is overprescribed and that the long-term effects of bisphosphonates are still unknown. 

Fast Facts

Name: Bisphosphonates are a class of drug which include prescription forms such as Actonel, Aredia, Boniva, Fosamax, Skelid, and Zometa
Generic: Generics include alendronate
Manufacturer: Varies. Primary manufacturers include Merck (Fosamax), Proctor & Gamble (Actonel) and Roche Therapeutics (Boniva).
Date approved: Varies. The first bisphosphonates were approved in the mid-1990s.
Status: Prescription only.
Approved uses: Treatment of bone-weakening diseases including cancer, osteoporosis, and Paget's disease.
Off-Label uses: Anti-fracture uses; however, the anti-fracture properties of bisphosphonates have not been proven.
Side effects: Bone pain, gastrointestinal symptoms, osteonecrosis of the jaw (ONJ/"dead jaw syndrom")
Related topics: Unsafe drugs, Fosamax
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Bisphosphonates: Overprescribed?

They increase in popularity on a daily basis: in fact, Fosamax was prescribed over 22 million times in 2005. They are touted as a miracle drug for the treatment and prevention of thinning and... read more

Bisphosphonates Can Cause Jaw Bone Death

They are increasingly prescribed in both women and men for the treatment and prevention of thinning and weakening bones (osteoporosis). But recent studies are showing that despite their popularity,... read more

View the Bisphosphonates Main Articles page here

Jury Verdicts Related to Bisphosphonates

______ VERDICT Dental malpractice alleged failure to proper insert implants, bridges and crowns loss of teeth Permanent cosmetic deformity.

View the Bisphosphonates Jury Verdicts page here

FDA Information Related to Bisphosphonates

February 2007 Monthly Safety Labeling

December 2006 Monthly Safety Labeling

View the Bisphosphonates FDA Information page here

MSN Newsfeeds Related to Bisphosphonates

Earnings Preview: Amgen

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View the Bisphosphonates MSN Newsfeeds page here

News Articles Related to Bisphosphonates

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View the Bisphosphonates News Articles page here

Books Related to Bisphosphonates

Workers' Compensation

Fosamax: A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

View the Bisphosphonates Books page here

Want to contact a Bisphosphonates attorney in District of Columbia?...Get a free case evaluation from one of our Bisphosphonates attorneys in District of Columbia now.

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